Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
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Twenty healthy volunteers were patch tested with three different moisturisers: empty chamber, sodium lauryl sulphate and a moisturizer known to be non-irritating. Skin reactions were evaluated by visual scoring, measurement of transepidermal water loss (TEWL) by an Evaporimeter, blood flow by laser Doppler flowmetry and electrical capacitance by a Corneometer. ⋯ The non-invasive patch test model was found useful for detecting irritant skin reactions to moisturisers.
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Moisturisers have many different effects on the skin, but increased plasticity is an important effect of moisturising. We have studied the short-term effects of six commonly used brands of moisturisers on the plasticity of normal and atopic skin. ⋯ The results suggest that high lipid moisturisers cause significantly greater changes in plasticity of normal skin than low-lipid moisturisers, and that atopic skin is influenced to a higher degree by moisturisers than normal skin.
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Transepidermal water loss (TEWL) is an important parameter for the determination of skin barrier function. The open chamber method has been established as the technique of choice in most dermatological laboratories for measurements of TEWL. However, the influence of the probe temperature on TEWL measurements has been the subject of recent controversial debates. In this study the relationship between TEWL measured with the Tewameter and temperature of the measuring probe was therefore investigated by comparing two different measuring techniques. ⋯ The final TEWL value was reached after shorter intervals for the preheated probe compared to the unheated probe (2.5 min vs. 4 min) for some measurements. However, preheating of the probe resulted in greater variability of the measurement values. Therefore, measurements with a preheated Tewameter probe is not be recommended.