Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
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Clinical Trial
Clearing of psoriasis documented by laser Doppler perfusion imaging contrasts remaining elevation of dermal expression levels of CD31.
Vascular modifications represent a key feature in psoriatic plaques. Previous research with Laser Doppler Perfusion Imaging (LDPI) revealed a remarkable heterogeneity in the cutaneous perfusion within homogenous-appearing psoriatic lesions. Insights in the relation between perfusion during treatment and related biological changes are lacking. ⋯ In the skin of good-responders the expression of dermal CD31(+) endothelium remains significantly elevated within the treated lesions compared with the distant uninvolved skin, whereas a marked reduction in the perfusion intensity and SUM score was found. This indicates that clinical improvement might outrun endothelial changes.
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In the absence of humidity receptors in human skin, the perception of skin wetness is considered a somatosensory experience resulting from the integration of temperature (particularly cold) and mechanical inputs. However, limited data are available on the role of the temperature sense. ⋯ We conclude that it is not the contact of the skin with moisture per se, but rather the integration of particular sensory inputs (amongst which coldness seems dominant) which drives the perception of skin wetness during the initial contact with a wet surface.
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Skin expansion is a physiological process that is defined as the ability of the human skin to increase its superficial area in response to stress or to a given deformation. Skin expanders are silicon bags that are implanted underneath the skin. Because the skin presents creep or relaxation, the resulting stress decreases after a time due to the imposed deformation. Skin expansions are used to reconstruct burned areas and breasts after a mastectomy or to hide scars. ⋯ fci, Correcting factor, which corrects the mathematical formulas using the experimental results, for i skin expander; i, geometry of the expander, round (c), rectangular (r), or crescent (cresc/cr); Sd , surface of the defect; Sds , surface area of the donor site; Sfi, surface area obtained using a mathematical calculation for the i skin expander; S¯fi, surface area obtained experimentally for the i skin expander; Sfi∗, corrected surface area obtained using a mathematical calculation for the i skin expander corrected by the correcting factor; S¯fi∗∗ extra flap of skin obtained by expansion for the i skin expander; Vii, internal volume infiltrated in the i skin expander; Vni, nominal internal volume of the i skin expander.
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Most traditional skin histological analysis methods are based on the light microscopy images, which can only provide limited information and low contrast results for pathology evaluation. Molecular hyperspectral imaging technology can provide both spatial and spectral information of skin sections, which is a new method for histological skin analysis. ⋯ Unlike traditional histological analysis with light microscopy, the molecular hyperspectral imaging technology can enhance the visualization of skin structures using their spectral signatures and their gray values. This technology has potential for the diagnosis and histopathologic characterization of different kind of skin cells.
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We analyzed skin heat conduction under moist and dry heat conditions to confirm the influence of moist heat on the skin and subcutaneous region. ⋯ Stratum corneum moisture levels and skin surface heat conductivity were higher in the moist heat condition and skin blood flow was significantly greater than that in skin exposed to dry heat. Therefore, moist heat is more efficient at warming the body than dry heat.