Journal of pediatric hematology/oncology
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J. Pediatr. Hematol. Oncol. · Jan 2014
Phyllodes tumor in survivors of childhood osteosarcoma: a single institution's experience.
We evaluate the incidence of second neoplasms in 86 patients with osteosarcoma (OS) of the extremities treated with different protocols of adjuvant chemotherapy. Three patients developed phyllodes tumors as the second neoplasm. One of these patients simultaneously developed a third cancer with therapy-related acute myeloid leukemia. ⋯ None had received prior radiotherapy before excision of phyllodes tumor. All the patients were female with a median age of 21.7 years at the time of presentation. As yet, that precise causation is unclear, but it can increase our understanding of carcinogenic processes, in general.
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J. Pediatr. Hematol. Oncol. · Oct 2013
The use of complementary and alternative medicine by irish pediatric cancer patients.
The use of complementary and alternative medicine (CAM) in the Irish pediatric cancer setting has not previously been established. ⋯ The high prevalence of CAM use demonstrated in this study and particularly the high use of CAM medication therapies underlines the importance of physicians asking routinely about CAM use in this population.
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J. Pediatr. Hematol. Oncol. · Oct 2013
The effects of propofol and ketamine on the cytokine levels of children with acute lymphoblastic leukemia.
The immune system of children with acute lymphoblastic leukemia (ALL) is affected by both the underlying disease and the chemotherapy. Children with ALL receive sedation for diagnostic and therapeutic procedures, which may contribute to immune competence alteration. The effects of propofol-ketamine combination on the immune system of children with ALL have not been investigated. ⋯ Sedation with propofol-ketamine combination did not modify the plasma concentration of the most measured cytokines and the T helper 1/2 ratio in children with ALL. There was a significant reduction in IL-8 concentration 24 hours after BMA associated with the concomitant administration of steroids and methotrexate. These data suggest that sedation with propofol-ketamine combination may not affect the immediate outcome of children with ALL.
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J. Pediatr. Hematol. Oncol. · Jul 2013
Historical ArticlePredictors for bacteremia in febrile sickle cell disease children in the post-7-valent pneumococcal conjugate vaccine era.
The objective of this study was to determine the incidence of bacteremia in febrile sickle cell disease (SCD) children before and after the 7-valent pneumococcal vaccine (PCV7), and to determine clinical factors associated with bacteremia following PCV7. ⋯ In febrile SCD children, the incidence of general bacteremia decreased over time. No decrease in pneumococcal bacteremia was found. The presence of a central venous line, absolute band count, clinical appearance, and age may help predict bacteremia in this population.
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J. Pediatr. Hematol. Oncol. · Jul 2013
Clinical TrialProspective surveillance study of blood stream infections associated with central venous access devices (port-type) in children with acute leukemia: an intervention program.
The use of intensive chemotherapy and central devices has improved patients survival, but it is associated with catheter-related blood-stream infections (CRBSI). An educational program was instituted for preventing CRBSI occurrence in acute leukemia pediatric patients having totally implanted central devices. The Centers of Disease Control and Prevention criteria were used as definition for CRBSI. ⋯ Six patients needed a central venous access device replacement. Our intervention program was successful to decrease the CRBSI rates and its intensification allowed a further decrease, approaching reported rates in this setting. Severe neutropenia at the time of central venous access device insertion was related to CRBSI occurrence and recurrence.