European journal of neurology : the official journal of the European Federation of Neurological Societies
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Randomized Controlled Trial Clinical Trial
Double-blind crossover trial of gabapentin in SPG4-linked hereditary spastic paraplegia.
Patients with hereditary spastic paraplegia (HSP) are often treated with antispastic drugs to relieve symptoms but documentation is lacking. In this study, gabapentin was tested in a double-blind crossover trial on a group of patients with HSP and linkage to the SPG4 locus. There was no difference between periods with gabapentin and placebo treatment in clinical assessment, self-reported parameters or paired transcranial magnetic stimulation evaluation of motor cortical excitability.