Oral diseases
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Randomized Controlled Trial
Vortioxetine versus other antidepressants in the treatment of burning mouth syndrome: An open-label randomized trial.
This randomized open-label trial compared the efficacy and tolerability of vortioxetine (15 mg/daily) with different antidepressants in the treatment of patients with burning mouth syndrome (BMS). ⋯ Vortioxetine was efficacious with a shorter latency of action and fewer AEs compared with other ADs.
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Randomized Controlled Trial
Effects of intramuscular morphine in men and women with temporomandibular disorder with myofascial pain.
This placebo-controlled randomized double-blinded clinical study assessed the analgesic efficacy of intramuscular morphine in TMD patients with myofascial pain and sex-dependent responses of the morphine treatment. ⋯ A single dose intramuscular morphine produced analgesic effects up to 48 hr in patients with myofascial pain. Intramuscular morphine elevated mechanical pain threshold and tolerance in the masseter only in male patients, suggesting sex differences in local morphine effects. No systemic effect of intramuscular morphine was detected.