Investigative radiology
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Investigative radiology · Dec 2010
Biopsy targeting gliomas: do functional imaging techniques identify similar target areas?
Because of the heterogeneous nature of glioma, biopsies performed should be targeted at the most anaplastic region. Several functional magnetic resonance imaging (MRI) or positron emission tomography (PET) techniques have been proposed for identifying the most anaplastic tumor area. However, it is unclear whether the recommended biopsy targets based on these various functional imaging modalities correspond with each other. Thus, the purpose was to evaluate whether they identify similar target areas. ⋯ Both imaging techniques that depict microcirculation and techniques that visualize proliferation identify similar target areas.
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Investigative radiology · Dec 2010
Comparative StudyEvaluation of gadodiamide versus gadobutrol for contrast-enhanced MR imaging in a rat brain glioma model at 1.5 and 3 T.
To compare equivalently-dosed (0.1 mmol/kg) gadobutrol (Gadovist) and gadodiamide (Omniscan) in a rat brain glioma model with respect to lesion signal-to-noise (SNR), contrast-to-noise (CNR), and contrast enhancement (CE) at 1.5 and 3 T. Lesion enhancement with standard-dose gadobutrol in scans performed at 1.5 T was also compared with that of half-dose gadobutrol in scans performed at 3 T. ⋯ Gadobutrol (Gadovist) demonstrates superior lesion enhancement to equivalently-dosed gadodiamide (Omniscan) in the rat brain glioma model. These results are complemented by the improved observed and theoretical safety profile of the first agent, in particular with regard to nephrogenic systemic fibrosis. The ability to image with half-dose gadobutrol at 3 T without a statistically significant decrease in lesion enhancement, compared with 1.5 T, offers an additional theoretical safety margin and potential cost-savings.
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Investigative radiology · Oct 2010
Comparative StudyDynamic contrast-enhanced magnetic resonance imaging evaluation of VX2 carcinoma in a rabbit model: comparison of 1.0-M gadobutrol and 0.5-M gadopentetate dimeglumine.
To compare the enhancement characteristics and diagnostic performance of 1.0-M gadobutrol with those of 0.5-M gadopentetate dimeglumine in rabbit VX2 tumor models. ⋯ Using a 3.0-T magnet, equivalent doses of 1.0-M gadobutrol-enhanced MR imaging showed a superior degree of enhancement for a VX2 tumor than 0.5-M gadopentetate dimeglumine-enhanced MR imaging, and a significant preference for readers was noted for 1.0-M gadobutrol-enhanced MR imaging.
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Investigative radiology · Sep 2010
Comparative StudyIntravenous versus intra-articular delayed gadolinium-enhanced magnetic resonance imaging in the hip joint: a comparative analysis.
The purpose of this study was to investigate whether T1-mapping of hip joint with intra-articular delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (ia-dGEMRIC) is comparable to the already established intravenous (iv)-technique for assessing different grades of cartilage degeneration. ⋯ Prospective case series, Diagnostic study comparing different modalities of assessing status of hip joint cartilage: Level II evidence.
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Investigative radiology · Jul 2010
Intravascular functional maps of common neurovascular lesions derived from volumetric 4D CT data.
Current computed tomography angiography (CTA) postprocessing tools do not support quantitative assessment of intravascular physiology. Dynamic volumetric CT, acquired at a sufficiently high temporal resolution, is ideal for such analysis. Following preliminary experiments in flow phantoms, we examine the segmentation of blood vessels from 4D CT angiography by curve fit and encoding of functional blood flow information into the resulting functional intravascular maps. ⋯ The above approach to quantitative CT angiography provides a method of evaluating dynamic CTA data by means of intravascular functional maps. The techniques are broadly applicable in the clinical assessment of a variety of vascular diseases.