Investigative radiology
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Investigative radiology · Sep 2002
Comparative StudyHaemodialysis for the prevention of contrast-induced nephropathy: outcome of 31 patients with severely impaired renal function, comparison with patients at similar risk and review.
To investigate whether haemodialysis prevents contrast-induced nephropathy (definition: increase of serum-creatinine of >or= 0.5 mg/dL within 7 days). ⋯ Data provide no hint that haemodialysis prevents contrast-induced nephropathy. Therefore, postprocedural dialysis should be restricted to patients participating in clinical studies.
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Investigative radiology · May 2002
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialDouble-blind, efficacy evaluation of gadobenate dimeglumine, a gadolinium chelate with enhanced relaxivity, in malignant lesions of the brain.
The diagnostic efficacy of gadobenate dimeglumine (Gd BOPTA) was compared with that of gadodiamide (Gd DTPA-BMA) in patients with primary malignant tumors or metastases of the brain. ⋯ Gadobenate dimeglumine, used at slightly lower doses, is comparable to gadodiamide in terms of efficacy in imaging of malignant intraaxial brain lesions. As with other gadolinium chelates, higher doses (0.15 and 0.2 mmol/kg) of gadobenate dimeglumine offer greater diagnostic information.
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Investigative radiology · Mar 2002
Multicenter StudyIntrathecal gadolinium (gadopentetate dimeglumine) enhanced magnetic resonance myelography and cisternography: results of a multicenter study.
This cooperative multicenter human study was designed to evaluate the safety, magnetic resonance (MR) imaging characteristics, and clinical response to a single gadolinium contrast agent: gadopentetate dimeglumine. ⋯ This cooperative study demonstrates the general safety and feasibility of low dose (0.5-1.0 mL/ml) intrathecal gadopentetate dimeglumine administration. The potential useful clinical applications include the evaluation of obstructions and communications of the various subarachnoid spaces, spontaneous or traumatic/postsurgical craniospinal cerebrospinal fluid leaks, and subarachnoid space CSF flow and parenchymal CNS interstitial diffusion dynamics. This worldwide cooperative study seeks to progressively perform human studies for further definitive evaluation of the practical clinical applications, of the relationship of this technique to other imaging studies and modalities, and the long-term safety of the procedure in a larger number of subjects.
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Investigative radiology · Oct 2001
Individually adapted examination protocols for reduction of radiation exposure in chest CT.
To develop a simple directive for the reduction of radiation exposure without loss of diagnostic information in routine chest CT examinations. ⋯ By deriving mAs values from body weight estimation, an individually adapted protocol for chest CT can be recommended and easily employed in a clinical setting. With an adaptation of the tube current-time product based on the estimated body weight of the patient - 10 (body weight [kg] - 10 mAs), a well-balanced examination without significant loss of information, even in soft-tissue window settings, can be performed with this particular scanner. For this adapted mAs protocol, a mean reduction of radiation exposure of 45% was achievable, compared with the standard protocol. A maximum decrease per case down to 31 mAs was obtained, without relevant loss of image quality. Therefore, for other types of CT scanners, analogous protocols may be adapted.
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Investigative radiology · Sep 2001
Multiple-slice spin lock imaging of head and neck tumors at 0.1 Tesla: exploring appropriate imaging parameters with reference to T2-weighted spin-echo technique.
Spin lock imaging has been shown to be useful in characterizing head and neck tumors. The purposes of this study were to explore and develop multiple-slice spin lock gradient-echo (SL-GRE) sequences for head and neck imaging and to compare the tumor contrast on SL images to spin-echo (SE) T2-weighted images at 0.1 T. ⋯ The multiple-slice SL-GRE technique provides image contrast comparable to that of SE T2-weighted imaging for head and neck tumors at 0.1 T. With short locking pulse lengths and echo times, wide anatomic coverage and reduced motion and susceptibility artifacts can be achieved. The out-of-phase SL technique is useful in imaging salivary gland tumors.