Annals of internal medicine
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Review Meta Analysis
Epidural Corticosteroid Injections for Radiculopathy and Spinal Stenosis: A Systematic Review and Meta-analysis.
Use of epidural corticosteroid injections is increasing. ⋯ Epidural corticosteroid injections for radiculopathy were associated with immediate reductions in pain and function. However, benefits were small and not sustained, and there was no effect on long-term surgery risk. Limited evidence suggested no effectiveness for spinal stenosis.
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Review Meta Analysis
Cognitive Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis.
Because psychological approaches are likely to produce sustained benefits without the risk for tolerance or adverse effects associated with pharmacologic approaches, cognitive behavioral therapy for insomnia (CBT-i) is now commonly recommended as first-line treatment for chronic insomnia. ⋯ None. (PROSPERO registration number: CRD42012002863).
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Review Meta Analysis
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis.
Guidelines recommend statins as first-line therapy for dyslipidemia. Monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new lipid-lowering approach. ⋯ CRC 1116 Masterswitches in Myocardial Ischemia, German Research Council DFG.
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Review Meta Analysis
Optimal Timing of Antiretroviral Therapy Initiation for HIV-Infected Adults With Newly Diagnosed Pulmonary Tuberculosis: A Systematic Review and Meta-analysis.
Initiation of antiretroviral therapy (ART) during tuberculosis (TB) treatment remains challenging. ⋯ None. (PROSPERO registration: CRD42012001884).
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Review Meta Analysis
Effects of blood pressure reduction in mild hypertension: a systematic review and meta-analysis.
Effects of blood pressure reduction in persons with grade 1 hypertension are unclear. ⋯ Swedish Heart-Lung Foundation, Swedish Research Council, Australian Research Council, and National Health and Medical Research Council of Australia.