Annals of internal medicine
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Randomized Controlled Trial
In older inpatients with polypharmacy, medication optimization did not improve outcomes at 48 wk.
Ie K, Hirose M, Sakai T, et al. Medication optimization protocol efficacy for geriatric inpatients: a randomized clinical trial. JAMA Netw Open. 2024;7:e2423544. 39078632.
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Randomized Controlled Trial Multicenter Study
Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.
The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain. ⋯ National Heart, Lung, and Blood Institute.
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Randomized Controlled Trial
Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.
Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits. ⋯ National Institutes of Health.
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Randomized Controlled Trial
In symptomatic knee OA, adding oral methotrexate to usual analgesia reduced pain at 6 mo.
Kingsbury SR, Tharmanathan P, Keding A, et al. Pain reduction with oral methotrexate in knee osteoarthritis: a randomized, placebo-controlled clinical trial. Ann Intern Med. 2024;177:1145-1156. 39074374.
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Randomized Controlled Trial
In adults with BMI ≥27 kg/m2 and CVD, but without diabetes, semaglutide reduced MACE, regardless of baseline HbA1c level.
Lingvay I, Deanfield J, Kahn SE, et al; SELECT Trial Investigators. Semaglutide and cardiovascular outcomes by baseline HbA1c and change in HbA1c in people with overweight or obesity but without diabetes in SELECT. Diabetes Care. 2024;47:1360-1369. 38907684.