Annals of internal medicine
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Thromboembolic disease is the most frequent medical complication of arthroplasty. ⋯ Compared with LMWH, lower doses of oral factor Xa inhibitors can achieve a small absolute risk reduction in symptomatic deep venous thrombosis without increasing bleeding.
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Review Meta Analysis
Antivirals for treatment of influenza: a systematic review and meta-analysis of observational studies.
Systematic reviews of randomized, controlled trials in patients with influenza suggest a lack of evidence about the effects of antiviral therapy on several patient-important outcomes of influenza. ⋯ Therapy with oral oseltamivir and inhaled zanamivir may provide a net benefit over no treatment of influenza. However, as with the randomized trials, the confidence in the estimates of the effects for decision making is low to very low. PRIMARY FUNDING SOURCES: World Health Organization and McMaster University.
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Review Meta Analysis
Vitamin D with or without calcium supplementation for prevention of cancer and fractures: an updated meta-analysis for the U.S. Preventive Services Task Force.
Studies suggest that vitamin D supplementation may reduce cancer and fracture risks. ⋯ Agency for Healthcare Research and Quality.
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Review Meta Analysis
Venous thromboembolism prophylaxis in hospitalized medical patients and those with stroke: a background review for an American College of Physicians Clinical Practice Guideline.
Venous thromboembolism prophylaxis has been recommended for nonsurgical patients, but its effectiveness remains uncertain. ⋯ American College of Physicians.
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Review Meta Analysis
Clinical decision rules for excluding pulmonary embolism: a meta-analysis.
Clinical probability assessment is combined with d-dimer testing to exclude pulmonary embolism (PE). ⋯ Clinical decision rules and gestalt can safely exclude PE when combined with sensitive d-dimer testing. The authors recommend standardized rules because gestalt has lower specificity, but the choice of a particular rule and d-dimer test depend on both prevalence and setting.