Annals of internal medicine
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Ondansetron compared with high-dose metoclopramide in prophylaxis of acute and delayed cisplatin-induced nausea and vomiting. A multicenter, randomized, double-blind, crossover study.
To compare the efficacy and side effects of ondansetron with those of high-dose metoclopramide in treating acute and delayed cisplatin-induced nausea and vomiting. ⋯ Ondansetron is significantly more effective than metoclopramide in preventing acute nausea and vomiting. In the delayed phase, the results of both drugs were disappointing, although metoclopramide's effect on delayed nausea was superior. Patients preferred ondansetron.
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Case Reports Multicenter Study Clinical Trial
Anticytoplasmic autoantibodies: their immunodiagnostic value in Wegener granulomatosis.
To determine disease specificity and sensitivity of anticytoplasmic autoantibodies (ACPA) for Wegener granulomatosis, as well as their value as a marker of disease activity. ⋯ Testing for ACPA in serum of patients with Wegener granulomatosis is valuable for differential diagnosis; furthermore, APCA can be used as a marker to follow disease activity. A new type of ELISA yielded the same results as indirect immunofluorescence for the specificity, sensitivity, and correlation with disease activity of ACPA.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Methylprednisolone therapy in patients with severe alcoholic hepatitis. A randomized multicenter trial.
To determine the efficacy of a corticosteroid in reducing the short-term mortality of patients with severe alcoholic hepatitis. ⋯ Methylprednisolone therapy decreases short-term mortality in patients with severe alcoholic hepatitis manifested either by spontaneous hepatic encephalopathy or a markedly elevated discriminant function value.