Annals of internal medicine
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Randomized Controlled Trial Multicenter Study
Effect of Acupuncture on Neurogenic Claudication Among Patients With Degenerative Lumbar Spinal Stenosis : A Randomized Clinical Trial.
Acupuncture may improve degenerative lumbar spinal stenosis (DLSS), but evidence is insufficient. ⋯ 2019 National Administration of Traditional Chinese Medicine "Project of building evidence-based practice capacity for TCM-Project BEBPC-TCM" (NO. 2019XZZX-ZJ).
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Comment Randomized Controlled Trial
In adult inpatients with a UTI, CPOE-based vs. routine stewardship reduced extended-spectrum antibiotic use.
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Comment Randomized Controlled Trial
In ASCVD, an inclisiran-first strategy reduced LDL-C levels and statin discontinuation at 330 d.
Koren MJ, Rodriguez F, East C, et al. An "inclisiran first" strategy vs usual care in patients with atherosclerotic cardiovascular disease. J Am Coll Cardiol. 2024;83:1939-1952. 38593947.
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Comment Randomized Controlled Trial Multicenter Study
In patients at high risk for RA, abatacept reduced inflammation and RA development at 6 mo.
Rech J, Tascilar K, Hagen M, et al. Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo-controlled trial. Lancet. 2024;403:850-859. 38364841.
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Comment Randomized Controlled Trial
In adults with COVID-19 and severe hypoxemia, lower vs. higher oxygenation targets increased days alive without life support.
Nielsen FM, Klitgaard TL, Siegemund M, et al; HOT-COVID Trial Group. Lower vs higher oxygenation target and days alive without life support in COVID-19: the HOT-COVID randomized clinical trial. JAMA. 2024;331:1185-1194. 38501214.