Annals of internal medicine
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The commonly accepted threshold of glomerular filtration rate (GFR) to define chronic kidney disease (CKD) is less than 60 mL/min/1.73 m2. This threshold is based partly on associations between estimated GFR (eGFR) and the frequency of adverse outcomes. The association is weaker in older adults, which has created disagreement about the appropriateness of the threshold for these persons. In addition, the studies measuring these associations included relatively few outcomes and estimated GFR on the basis of creatinine level (eGFRcr), which may be less accurate in older adults. ⋯ Swedish Research Council, National Institutes of Health, and Dutch Kidney Foundation.
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Clinical Trial
In adults with stable angina, PCI vs. a placebo procedure reduced angina symptoms at 12 wk.
Rajkumar CA, Foley MJ, Ahmed-Jushuf F, et al; ORBITA-2 Investigators. A placebo-controlled trial of percutaneous coronary intervention for stable angina. N Engl J Med. 2023;389:2319-2330. 38015442.
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In addition to the physical disease burden of the COVID-19 pandemic, concern exists over its adverse mental health effects. ⋯ None.