Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Oct 2021
Meta AnalysisDiagnostic Value of Urinary MicroRNAs for Bladder Cancer in Asia.
This study aimed to explore the diagnostic performance of urinary microRNAs (miRNAs) in bladder cancer (BC) in the Asian population. PubMed, Embase, Web of Science and Cochrane Library were searched for relevant literature on the diagnostic performance of miRNAs for BC in the Asian population. Subsequently, quality assessment on diagnostic accuracy studies-2 (QUADAS-2) was used for evaluating the quality of the included literature, and Stata version 15.0 for statistical analysis. ⋯ Additionally, the area under the curve (AUC) was 0.85 in the summary receiver operating characteristic (SROC) curve, and the diagnostic odds ratio (DOR) was 12.39 (95%CI: 9.00-17.07). In conclusion, urinary miRNAs show good performance in diagnosing BC in Asia, and, therefore, can serve as effective biomarkers for early clinical screening and auxiliary diagnosis of BC. Key Words: MicroRNAs, Bladder cancer, Diagnostic value, Meta-analysis.
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J Coll Physicians Surg Pak · Oct 2021
Randomized Controlled TrialEffect of Apical Patency on Postoperative Pain after Single-visit Endodontic Treatment in Necrotic Teeth with Asymptomatic Apical Periodontitis: A Randomised Control Trial.
To find out the effect of apical patency on postoperative pain after single-visit endodontic treatment in necrotic teeth with asymptomatic apical periodontitis. ⋯ Maintaining apical patency in necrosed teeth with asymptomatic apical periodontitis does not significantly reduce postoperative pain after single visit endodontic treatment. Key Words: Apical patency, Postoperative pain, Asymptomatic apical periodontitis.
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J Coll Physicians Surg Pak · Oct 2021
Randomized Controlled TrialEffectiveness of Mobile Health Augmented Cardiac Rehabilitation on Behavioural Outcomes among Post-acute Coronary Syndrome Patients: A Randomised Controlled Trial.
To determine the effectiveness of mobile health augmented cardiac rehabilitation (MCard) on behavioural factors among post-acute coronary syndrome (post-ACS) patients. ⋯ The MCard positively impacts the post-ACS participants' behaviours in terms of physical activity, healthy eating, and salt restriction. MCard evidenced as a feasible intervention in terms of having lasting behaviour modification among this vulnerable patient population. Key Words: Acute coronary syndrome, Myocardial infarction, Cardiovascular diseases, Cardiac rehabilitation, Healthy diet, Physical activity, Smoking, Tobacco, Telemedicine, Lifestyle modification.
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J Coll Physicians Surg Pak · Oct 2021
Randomized Controlled TrialPost-hysteroscopy Duration of the Cook Balloon Uterine Stent Effect on the Re-adhesion Formation.
To compare duration of Cook balloon uterine stent on re-adhesions formation, and observe its effect on serum transforming growth factor β1 (TGF-β1) and plasminogen activator inhibitor-1 (PAI-1) levels in patients with intrauterine adhesions (IUA) undergoing hysteroscopic transcervical resection of adhesion (TCRA). ⋯ Placement of Cook balloon uterine stent for 37 days after hysteroscopic TCRA in patients with IUA can effectively prevent postoperative intrauterine re-adhesion, have few complications, low recurrence rate of IUA and high re-pregnancy rate, and reduce levels of serum TGF-β1 and PAI-1. Key Words: Intrauterine adhesions (IUA), Transcervical resection of adhesion (TCRA), Transforming growth factor β1 (TGF-β1), Plasminogen activator inhibitor-1 (PAI-1), Pregnancy.
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J Coll Physicians Surg Pak · Oct 2021
Observational StudyEffect of Temperature and Preservative on Neo-ethanol Formation in Postmortem Whole Blood Samples.
To determine the association of temperature, time duration, and preservatives with ethanol neo-genesis in postmortem whole blood samples. ⋯ Sodium fluoride (NaF) should be used as preservative to avoid ethanol neo-genesis during storage and transportation of blood samples for alcohol analysis. Cold chain maintenance is of pivotal importance to exclude false positive blood alcohol results. Key Words: Neo-ethanol, Neo-genesis, Ethylenediaminetetra acetic acid (EDTA), Sodium fluoride (NaF).