Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Jan 2022
Case ReportsA Case of IgG4-related Mesenteritis and Ankylosing Spondylitis.
Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory disease of unknown etiology and pathogenesis, which can affect all organs. The most commonly involved organs are the pancreas, hepatobiliary system, salivary glands, orbits and lymph nodes. Rarely, the thyroid, pituitary, aorta, lung and kidney may also be involved; mesenteric involvement is rare. ⋯ Anti-tumor necrosis factor alpha (anti-TNFα) treatment has been tried in refractory IgG4-RD cases; but this case is of great interest in terms of progressive presentation under treatment with etanercept, an anti-TNFα agent, which is also used for the treatment. But, IgG4-related mesenteritis with ankylosing spondylitis receiving anti-TNFα therapy, which has also been tried in the treatment of IgG4 disease, has not been reported in the literature. Key Words: IgG4-related disease, Mesenteritis, Ankylosing spondylitis.
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J Coll Physicians Surg Pak · Jan 2022
Observational StudyRelationship between Hemoglobin A1c and Fractional Flow Reserve Lesion Severity in Non-diabetic Patients.
To find out whether there is any correlation between the fractional flow reserve (FFR) that indicates the severity of coronary artery disease (CAD), and the HbA1c value in non-diabetic patients. ⋯ HbA1c, which shows the long-term glycemic index in non-diabetic individuals, is associated with the severity of CAD determined by the fractional flow reserve. Key Words: Coronary artery disease, fractional flow reserve, HbA1c.
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J Coll Physicians Surg Pak · Jan 2022
Randomized Controlled TrialDoes Interval between Breastfeedıng and Heel Lance Affect the Perception of Pain in Newborns?
To investigate whether the duration between breastfeeding and heel lance has an effect on babies' pain perception. ⋯ The duration between breastfeeding and heel lance may influence the perception of pain in newborns. Keeping this period short, may reduce the perception of pain. Key Words: Breastfeeding, Breast milk, Newborn, Pain.
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To evaluate the prognostic role of pan immune-inflammation value (PIV) in young breast cancer patients. ⋯ Higher PIV levels at the time of diagnosis can be another prognostic marker. However, to clarify the PIV prognostic value, it needs to be validated in larger, multi-centre prospective clinical studies. Key Words: Breast cancer, Pan immune-inflammation value (PIV), Prognosis, Young women.
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J Coll Physicians Surg Pak · Jan 2022
Case ReportsSuccessful Pregnancy Outcome in a Lady with Polyglandular Autoimmune Syndrome Type II.
We report a case of a lady who had polyglandular autoimmune syndrome type II (hypothyroidism, Addison's disease, vitiligo), who completed a successful pregnancy. Addison's disease (AD) was confirmed by the presence of anti-adrenal antibodies and hyponatremia. The patient had pre-pregnancy counselling about the need of antepartum, intrapartum and postpartum steroids. ⋯ The fetal growth was at 90th centile. Management in pregnancy, labour and postnatal period requires multidisciplinary care by the endocrinologist, obstetrician, midwife, anaesthetist and neonatologist. Key Words: Addison's disease, Hypothyroidism, Hyponatremia, Labour, Pregnancy.