Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Feb 2022
Meta AnalysisAssociation between Insulin Resistance and Cognitive Impairment.
The objective of the review was to assess the relationship between insulin resistance and cognitive impairment. Medline, Embase, Web of Science and Cochrane Library were searched. Two independent authors selected studies and extracted data. ⋯ The article showed a negative association between insulin resistance and cognition (R = - 0.262; 95% CI-0.309, - 0.215). There is evidence that insulin resistance may be a mechanism of cognitive impairment. Key Words: Insulin resistance, Insulin, Cognition, Cognitive impairment, Systematic review, Alzheimer's disease.