Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Mar 2022
Role of Betatrophin and Inflammation Markers in Type 2 Diabetes Mellitus, Prediabetes and Metabolic Syndrome.
To determine the association of betatrophin and inflammation factors in metabolic diseases such as diabetes, impaired fasting glucose, impaired glucose tolerance and metabolic syndrome. ⋯ The circulating betatrophin and TNF-α levels were increased in MetS, IFG and IGT. IL-6 was decreased in MetS compared to the healty controls. Further studies are needed to elucidate the role of betatrophin and inflammatory parameters in the development of T2DM and prediabetic syndromes, whether betatrophin could have clinical applications in the development of new antidiabetic agents. Key Words: Betatrophin, IL-6, TNF-alpha, Metabolic syndrome, Insulin resistance, Diabetes mellitus type 2.
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J Coll Physicians Surg Pak · Mar 2022
Observational StudyIncidental Detection of Inguinoscrotal Bladder Hernia with Associated Factors on 18F-fluorodeoxyglucose PET/CT Scans.
To evaluate the associated factors of inguinoscrotal bladder hernia (ISBH), which was detected on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scans. ⋯ This study reiterated the impact of PV and the parameters representing abdominal fat distribution on ISBH development. PET/CT scan provided valuable information regarding both the hernia contents and the associated factors in which the higher PV had a significant association for the development of ISBH as well as lower SFV/VFV that was more prominent in ISH with bowel. Key Words: Inguinoscrotal bladder hernia, 18F FDG PET/CT scan, Subcutaneous fat, Prostate volume, Visceral fat.
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J Coll Physicians Surg Pak · Mar 2022
Modulation of Oral Microflora during Helicobacter Pylori Eradication.
To analyse the saliva microbial abundance and composition by 16s rRNA sequence during Helicobacter pylori (H.pylori) eradication. ⋯ The diversity and richness of salivary microbiome were reduced in H.pylori-positive patient, and bismuth-containing quadruple therapy affected oral microbiota. Key Words: Helicobacter pylori, Saliva, Microbiota, RNA, Bismuth.
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J Coll Physicians Surg Pak · Mar 2022
Case ReportsFollicular Variant of Papillary Thyroid Carcinoma Presenting with Thoracic Vertebral Metastasis: A Rare Phenomenon.
Follicular variant of papillary thyroid carcinoma (FV-PTC) often follows nodal spread; and hematogenous spread is rare. A 77-year male presented to the Neurosurgery Outpatient Clinic with complaints and examination findings of spinal cord compression (SCC) by a mass at the 11th thoracic vertebra (T11). Subtotal mass excision, thoracic corpectomy with cage reconstruction, laminectomy, and posterior spinal stabilisation were performed. ⋯ Even four years after the total thyroidectomy, the neurological status of the patient was still stable and neither tumoral recurrence nor a new metastasis was detected. In the literature, the number of cases with FV-PTC presenting with SCC due to spinal metastasis is limited. Key Words: Thoracic vertebrae, Metastasis, Papillary thyroid carcinoma, Spinal cord compression.
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J Coll Physicians Surg Pak · Mar 2022
The Efficacy of an Initial Prednisone Monotherapy Regimen on PLA2R-associated Idiopathic Membranous Nephropathy.
The aim of this study was to evaluate the efficacy and safety of prednisone monotherapy for phospholipase A2 receptor (PLA2R)-associated idiopathic membranous nephropathy (IMN). This was a retrospective cohort study involving 32 patients enrolled between January 2017 and June 2019 at Beijing Friendship Hospital, Capital Medical University, Beijing, China. Seventeen patients received prednisone monotherapy, and 15 received the Ponticelli regimen. ⋯ Four and three patients relapsed in the prednisone monotherapy and Ponticelli regimen groups, respectively (p = 0.99). Initial prednisone monotherapy had similar efficacy and safety compared with the Ponticelli regimen for PLA2R-associated IMN. Key Words: PLA2R-associated idiopathic membranous nephropathy, Ponticelli regimen, Prednisone monotherapy.