Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Mar 2022
Relationships among Immune Score, TCF21 Methylation, Risk-factor Level, and Prognosis in Prostate Cancer.
To determine whether the immune score and methylation levels of transcription factor 21 (TCF21) could be used as independent diagnostic indicators and prognostic predictors in prostate cancer (PCA). ⋯ The immune score and TCF21 methylation could be used as independent indicators for the diagnosis and prognosis of PCA. Key Words: Prostatic neoplasms, Immunity cellular, DNA methylation.
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J Coll Physicians Surg Pak · Mar 2022
Observational StudyIntralesional Epidermal Growth Factor for Diabetic Foot Ulcers.
To determine the role of the intralesional recombinant epidermal growth factor (rEGF) in the healing and prevention of extremity amputation in advanced diabetic foot ulcer patients. ⋯ Recombinant epidermal growth factor is highly effective for the treatment of diabetic foot ulcers and prevention of extremity amputation. Intralesional rEGf provides efficient and safe wound healing/closure in patients with diabetic foot ulcers. Key Words: Amputation, Epidermal growth factor, Diabetic foot, Wound healing.
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J Coll Physicians Surg Pak · Mar 2022
Case ReportsPituitary Stalk Interruption Syndrome in a 54-year Adult Male.
Pituitary stalk interruption syndrome (PSIS) is a rare disease with isolated growth hormone deficiency or multiple anterior pituitary hormone deficiencies; and is characterised by a thin or absent pituitary stalk, hypoplasia of the adenohypophysis, and ectopic neurohypophysis. The literature have reported primarily on cases of infants and young people, and there are few reports in adults. A case is presented here of a 54-year male, who reported dizziness accompanied by fatigue and anorexia for more than 20 days; and the results from the blood tests showed a general decline in growth hormone, thyrotropin, and sex hormone levels. ⋯ In summary, PSIS can also occur in adults. In the suspected cases, magnetic resonance imaging should be done in time to diagnose and manage it appropriately early in the course of the disease. Key Words: Pituitary stalk interruption syndrome, Pituitary hormone deficiency, Adults.
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J Coll Physicians Surg Pak · Mar 2022
Can First-trimester AST to Platelet Ratio Index Scores Predict HELLP Syndrome?
Null.