Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Apr 2024
Meta AnalysisProphylactic Cranial Irradiation in Limited-Stage Small Cell Lung Cancer: A Meta-Analysis.
The role of prophylactic cranial irradiation (PCI) in limited-stage small cell lung cancer (LS-SCLC) has been questioned in the era of magnetic resonance imaging (MRI). The purpose of this study was to re-evaluate the efficacy of PCI in patients with LS-SCLC. Three electronic databases were searched, including PubMed, Embase, and the Cochrane Library from January 2012 to April 2022. All relevant publications were included based on the inclusion criteria, and survival data and brain metastasis (BM) rates were extracted and pooled. ⋯ The authors found that the PCI effects on OS were independent of region and the use of brain imaging after initial treatment. These findings demonstrate that PCI improves OS and PFS while decreasing the risk of BM in patients with LS-SCLC, implying that PCI remains necessary even in the MRI era. Key Words: Prophylactic cranial irradiation, Small cell lung cancer, Magnetic resonance imaging, Brain metastasis.
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J Coll Physicians Surg Pak · Apr 2024
Randomized Controlled TrialTreatment for Resistant Hypertension Under the Guidance of Pharmacogenomics: A Randomised Controlled Open-Label Trial.
To evaluate the efficacy and safety of pharmacogenomics (PGx)-guided treatment in individuals with resistant hypertension (RH). ⋯ Resistant hypertension, Treatment, Pharmacogenomics, Clinical study.
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J Coll Physicians Surg Pak · Apr 2024
Randomized Controlled TrialEvaluation of Postoperative Pain after Using Dexamethasone Intracanal Rinse in Irreversible Pulpitis.
To evaluate the efficacy of dexamethasone as a final intracanal rinse in relieving postoperative pain of teeth with symptomatic irreversible pulpitis. ⋯ Irreversible pulpitis, Dexamethasone, Postoperative pain, Pulpectomy.
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J Coll Physicians Surg Pak · Apr 2024
Genotypic Frequency of Rh Cw Antigen in Blood Donors of Northern Pakistan.
To determine the genotypic frequency of Rh Cw antigen in blood donors of Northern Pakistan. ⋯ Alloimmunisation, Blood donors, HDFN, Phenotype, Rh antigens, Transfusion.
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J Coll Physicians Surg Pak · Apr 2024
Are We Providing Enough Information to the Pathologists? An Audit of Filling of Histopathology Request Forms for Surgically Resected Tumours.
To analyse quantitatively the adequacy of demographics of clinical information and highlight specific areas of neglect, by assessing the adequacy of filling out histopathology request forms. ⋯ Histopathology, Request forms, Tumours, Audit.