Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Sep 2024
Randomized Controlled TrialIntrathecal Dexmedetomidine as an Adjuvant to Low Dose Hyperbaric 0.5% Bupivacaine on Haemodynamic Parameters in Patients Undergoing Transurethral Resection of Prostate.
To determine the role of dexmedetomidine in potentiating the local anaesthetic efficacy of a low dose of bupivacaine when used as an adjuvant. ⋯ Adjuvants, Dexmedetomidine, Spinal anaesthesia, Transurethral Resection of Prostate.
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J Coll Physicians Surg Pak · Sep 2024
Microplastic in Gastric Fasting Liquid and Associated Gastric Pathology.
To determine the presence of microplastics in the stomach, and the relationship between pathological changes in stomach tissue and microplastics. ⋯ H. pylori, Intestinal metaplasia, Inflammation, Microplastic, Plastic, Sydney classification.
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J Coll Physicians Surg Pak · Sep 2024
LetterComment on: Effect of Pap Smear Cytology, HPV Genotyping On the Concordance of Colposcopy and Conization Results.
Null.
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J Coll Physicians Surg Pak · Sep 2024
Meta AnalysisInclisiran Treatment for Cardiovascular Disease Risk Reduction: A Systematic Review and Meta-Analysis.
This study was a meta-analysis of patient data to investigate the therapeutic effects of inclisiran on LDL-C, PCSK9, and TC in patients with atherosclerosis. Authors searched the Cochrane Library, Pubmed, EMBASE, and Web of Science databases for randomised controlled trials. Data of 4,731 subjects from five randomised clinical trials were included in this analysis. ⋯ They exhibited significant reductions in total cholesterol protein levels ((MD) -1.477; 95% CI -1.585 to -1.369; p <0.001; I2 = 46.7%). Inclisiran reduced LDL-C and PCSK9 levels as well as TC and Apo B levels significantly in patients with atherosclerotic cardiovascular disease (ASCVD). Key Words: Inclisiran, Low-density lipoprotein cholesterol, Atherosclerosis, Adverse events, Meta-analysis.