Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Jul 2022
Observational StudyAnti-Phospholipase A2 Receptor Antibodies in Biopsy-Proven Idiopathic Membranous Nephropathy: A Report from the Pakistani Population.
This study aimed to determine the percentage of anti-phospholipase A2 receptor (PLA2R) autoantibody positivity in a cross-section of 74 Pakistani patients with biopsy-proven idiopathic membranous nephropathy. It was an observational study conducted from December 2018 to June 2019. Seventy-four (n=74) consecutive biopsy-proven cases of membranous nephropathy, aged between 12-60 years, were included. ⋯ Anti-PLA2R antibodies were detected in approximately half of the diagnosed idiopathic membranous nephropathy cases. However, this percentage was much lower than the studies conducted on other populations around the globe, indicating a possible pathogenic role of other antigens in our population. Key Words: Membranous nephropathy, Phospholipase A2 receptors, Renal biopsy.
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J Coll Physicians Surg Pak · Jul 2022
Case ReportsA Case of Euglycemic Diabetic Ketoacidosis due to Empagliflozin Use in a Patient with Type 1 Diabetes Mellitus.
Euglycemic diabetic ketoacidosis is characterised by serum blood glucose <250 mg/dl, arterial blood pH <7.35, and the presence of ketones in urine or blood. Here, we present a 36-year female with type-1 diabetes mellitus, a case of euglycemic diabetic ketoacidosis, who was admitted to the emergency unit with nausea, vomiting, and confusion after using empagliflozin, which was added to her treatment one month ago. She was followed up in the intensive care unit for four days. ⋯ Euglycemic diabetic ketoacidosis should be kept in mind as a differential diagnosis in patients with type-1 diabetes and type-2 diabetes presenting with acidosis. Attention should be paid to the patients' medications and whether there are SGLT-2 inhibitors among these drugs. Key Words: Diabetes mellitus, Sodium-glucose co-transporter-2 inhibitors, Euglycemic diabetic ketoacidosis, Empagliflozin.
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To investigate the roles of cytokines in the etiopathogenesis of idiopathic granulomatous mastitis (IGM). ⋯ Idiopathic granulomatous mastitis, Cytokine, Autoimmunity, Smoking.
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J Coll Physicians Surg Pak · Jul 2022
TNF-α (G308A) Polymorphism and Vascular Parkinson Complicated with Pulmonary Infection.
To analyse relationship between tumour necrosis factor-α (TNF-α) (G308A) polymorphism and Vascular Parkinson (VP) complicated with pulmonary infection. ⋯ Tumor necrosis factor-α (TNF-α), Polymorphism, Vascular Parkinson (VP), Pulmonary infection.
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J Coll Physicians Surg Pak · Jul 2022
Necrotising Fasciitis of the Abdominal Wall: A Lethal Gastrostomy-associated Complication.
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