Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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Melanoma is one of the most malignant forms of skin cancer; with a rapidly increasing prevalence. Early-stage melanoma is curable, but advanced metastatic melanoma is almost always fatal, and patients with such advanced disease have short median survival. Surgery and radiotherapy play a limited role in the treatment of metastatic melanoma. ⋯ While the prognosis is currently unpromising, chemotherapy plays a palliative role for patients with metastatic melanoma. The toxicity of treatment regimens based on DTIC and TMZ do not differ significantly, although TMZ is costlier. These findings provide a reference for future researchers via a comprehensive analysis of the relevant literature.
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J Coll Physicians Surg Pak · Sep 2015
Clinical Safety and Parameters of Maximum Oxygen Uptake (VO₂Max) Testing in Pakistani Patients With Heart Failure.
To determine the parameters of maximum oxygen uptake (VO2max) in a Pakistani systolic heart failure cohort and its safety in a clinical setting. ⋯ Cardiopulmonary exercise testing in a high-risk heart failure cohort is safe and provides information beyond the routine clinical evaluation of heart failure patients.
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J Coll Physicians Surg Pak · Sep 2015
Association Between Polymorphism in the Human Cathepsin L (CTSL1) Promoter with Hypertension in the Uygur, Kazak and Han Populations in China.
To systemically investigate the association between the polymorphism (rs3118869) in cathepsin Lenzyme gene with hypertension in three ethnic groups (Han, Kazak and Uygur) in China. ⋯ The study results indicate the A-allele of rs3118869 is a protective factor in hypertension.
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J Coll Physicians Surg Pak · Sep 2015
Predicting Prognosis in Hepatocellular Carcinoma: Comparison of Staging Systems in Pakistani Cohort.
To determine the clinical, biochemical and radiological prognostic indicators and to compare the performance of six staging systems in patients of hepatocellular carcinoma (HCC). ⋯ Male gender, presence of portal vein thrombosis, low serum albumin, large tumor size and high AFP level are poor prognostic indicators in patients of HCC. CLIP has better performance in predicting mortality.
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J Coll Physicians Surg Pak · Aug 2015
Observational StudyPaediatric Percutaneous Nephrolithotomy (PCNL).
To describe Paediatric Percutaneous Nephrolithotomy (PCNL) in terms of safety and efficacy in a group of 26 children. ⋯ PCNL is a safe and effective way of treating renal stones in paediatric age group.