Spinal cord
-
Comparative Study
Post-traumatic moderate systemic hypothermia reduces TUNEL positive cells following spinal cord injury in rat.
A standardized animal model of contusive spinal cord injury (SCI) with incomplete paraplegia was used to test the hypothesis that moderate systemic hypothermia reduces neural cell death. Terminal deoxynucleotidyl transferase [TdT]-mediated deoxyuridine triphosphate [dUTP] nick-end labeling (TUNEL) staining was used as a marker of apoptosis or cell damage. ⋯ These results indicate that systemic hypothermia has a neuroprotective effect following SCI by attenuating post-traumatic TPC.