The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
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Int. J. Tuberc. Lung Dis. · Jun 2015
Multicenter Study Comparative StudyPyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance.
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern. ⋯ pncA mutations associated with PZA resistance were found almost exclusively in MDR-TB strains, underlining the importance of determining PZA resistance when treating MDR- or XDR-TB.
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Int. J. Tuberc. Lung Dis. · Jun 2015
Diabetes mellitus is associated with cavities, smear grade, and multidrug-resistant tuberculosis in Georgia.
National tuberculosis (TB) treatment facility in the country of Georgia. ⋯ DM and pre-DM were common among adults with newly diagnosed pulmonary TB in Tbilisi, Georgia, and DM was associated with more clinical symptoms, and MDR-TB, at presentation.
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Int. J. Tuberc. Lung Dis. · May 2015
Multicenter StudyRole of confirmatory interferon-gamma release assays in school outbreaks of tuberculosis in South Korea.
To investigate the usefulness of confirmatory QuantiFERON(®) (QFT) testing among tuberculin skin test (TST) positive contacts to diagnose latent tuberculous infection (LTBI) in tuberculosis (TB) outbreaks among adolescents. ⋯ A confirmatory QFT for TST+ contacts could reduce the number of candidates for LTBI treatment after school TB outbreaks.
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A tertiary care academic medical centre. ⋯ CXCR3 ligands may be useful surrogate markers for diagnosing active TB and for assessing TB patients clinically.