British journal of anaesthesia
-
Randomized Controlled Trial Clinical Trial
Magnesium and coronary revascularization.
Twenty patients, who underwent coronary revascularization without cardioplegic arrest, were given (during cardiopulmonary bypass) either magnesium chloride 16 mmol in 10 ml of water (magnesium group) or 10 ml of water alone (control group). Plasma and urinary magnesium concentrations were measured for 24 h after operation. ECG was recorded continuously during this period. ⋯ Urinary magnesium excretion was higher in the magnesium group, with 58% of the administered magnesium excreted in the first 24 h. The observed incidence of frequent or ventricular arrhythmias was 22% in the magnesium group compared with 63% in the control group. No significant differences in QTcorr intervals were observed between the groups.
-
Randomized Controlled Trial Comparative Study Clinical Trial
Postoperative analgesia by continuous extradural infusion of bupivacaine and diamorphine.
Three solutions administered by continuous extradural infusion for postoperative analgesia were compared in a randomized, double-blind manner. All patients underwent major abdominal gynaecological surgery and received 0.125% bupivacaine in 0.9% saline, diamorphine in 0.9% saline (0.5 mg in 15 ml) or diamorphine mixed with 0.125% bupivacaine (0.5 mg in 15 ml), at a rate of 15 ml h-1. The bupivacaine-diamorphine mixture provided significantly superior analgesia compared with either bupivacaine or diamorphine alone. No major side effects were encountered.