British journal of anaesthesia
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Randomized Controlled Trial
Effect of dexamethasone in combination with caudal analgesia on postoperative pain control in day-case paediatric orchiopexy.
Dexamethasone has a powerful anti-inflammatory action and has demonstrated reduced morbidity after surgery. The aim of this study was to examine the effects of a single i.v. dose of dexamethasone in combination with caudal block on postoperative analgesia in children. ⋯ Intravenous dexamethasone 0.5 mg kg(-1) in combination with a caudal block augmented the intensity and duration of postoperative analgesia without adverse effects in children undergoing day-case paediatric orchiopexy.
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Letter Randomized Controlled Trial
Bonfils intubating fibrescope in normal paediatric airways.
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Randomized Controlled Trial
Intravenous lidocaine infusion reduces bispectral index-guided requirements of propofol only during surgical stimulation.
I.V. lidocaine reduces volatile anaesthetics requirements during surgery. We hypothesized that lidocaine would also reduce propofol requirements during i.v. anaesthesia. ⋯ The sparing effect of lidocaine on anaesthetic requirements seems to be mediated by an anti-nociceptive action.
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Randomized Controlled Trial
Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model.
The objective of this study was to develop a pharmacokinetic (PK) model to characterize the influence of obesity on propofol PK parameters. ⋯ We have derived a population PK model using obese and non-obese data to characterize propofol PK over a wide range of body weights. An allometric model using TBW as the size descriptor of volumes and clearances was superior to other size descriptors to characterize propofol PK in obese patients.
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Randomized Controlled Trial
Evaluation of the surgical stress index during spinal and general anaesthesia.
Although in modern anaesthesia, monitoring depth of anaesthesia and quality of neuromuscular block are routine, monitoring of analgesia still remains challenging. Recently, the surgical stress index (SSI), derived from finger photoplethysmographic signal, was introduced as a surrogate variable reflecting the nociception-antinociception balance. This study aimed at evaluating the SSI in patients undergoing regional anaesthesia either alone or combined with sedation compared with patients undergoing general anaesthesia (GA). ⋯ In fully awake patients under spinal anaesthesia, the SSI does not reflect the nociception-antinociception balance. This may be due to the influence of mental stress on the sympathetic nervous system. Even light sedation attenuates these influences.