British journal of anaesthesia
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Randomized Controlled Trial
Postoperative impairment of motor function at train-of-four ratio ≥0.9 cannot be improved by sugammadex (1 mg kg-1).
Recovery of train of four ratio to > 0.9 signifies adequate recovery of muscle function after neuromuscular blockade.
pearl -
This study evaluated efficacy and safety of sugammadex 4 mg kg(-1) for deep neuromuscular blockade (NMB) reversal in patients with severe renal impairment (creatinine clearance [CLCR] <30 ml min(-1)) vs those with normal renal function (CLCR ≥80 ml min(-1)). ⋯ NCT00702715.