British journal of anaesthesia
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Randomized Controlled Trial Multicenter Study
Hypersensitivity incidence after sugammadex administration in healthy subjects: a randomised controlled trial.
We evaluated the incidence of hypersensitivity or anaphylaxis after repeated single-dose sugammadex administration in non-anaesthetised adults. ⋯ NCT02028065.
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Randomized Controlled Trial
Sugammadex hypersensitivity and underlying mechanisms: a randomised study of healthy non-anaesthetised volunteers.
We investigated potential for hypersensitivity reactions after repeated sugammadex administration and explored the mechanism of hypersensitivity. ⋯ http://www.clinicaltrials.gov NCT00988065; Protocol number P06042.
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Observational Study
Validity and reliability of an objective structured assessment tool for performance of ultrasound-guided regional anaesthesia.
We examined the validity and reliability of the previously developed criterion-referenced assessment checklist (AC) and global rating scale (GRS) to assess performance in ultrasound-guided regional anaesthesia (UGRA). ⋯ Both assessments differentiated between individuals who had performed fewer (≤30) and many (>100) blocks in the preceding year, supporting construct validity. It also established concurrent validity and overall reliability. We recommend that both tools can be used in UGRA assessment.
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Local anesthetic myotoxicity may be clinically significant, particularly with bupivacaine, at higher LA concentrations and with longer exposure.
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