International journal of clinical practice
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Int. J. Clin. Pract. · Aug 2021
Evaluation of Spontaneous Reduction among the Invagination Cases Admitted to the Pediatric Emergency Department; Retrospective Study.
We aimed to determine the factors that determine the conditions in cases of invagination with spontaneous reduction. ⋯ Invagination is one of the surgical emergencies. With the widespread use of USG, most of these cases are followed up by clinical and USG follow-up in paediatric emergency services. Spontaneous reduction frequently develops in cases of intussusception with small bowel localisation and short bowel segment (less than 3 cm).
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Int. J. Clin. Pract. · Aug 2021
Peripheral blood levels of CXCL10 are a useful marker for diabetic polyneuropathy in subjects with type 2 diabetes.
Diabetic peripheral neuropathy (DPN) is a chronic complication of diabetes mellitus associated with high morbidity and mortality. Major risk factors for DPN include metabolic changes, duration of diabetes, nerve ischaemia and derangements in regeneration and nerve repair programmes. Chemokines have been previously implicated in the pathogenesis of various neuropathies and neuropathic pain processes. The aim of this pilot study was to evaluate the association between the plasma levels of chemokines (CXCL9, CXCL10 and CXCL11) in the presence of DPN in a cohort of type 2 diabetes (T2D) patients. ⋯ Increased circulating levels of CXCL10 were associated with DPN in T2D patients, suggesting a role of this chemokine in the DPN. Determination of CXCL10 levels could be used as a marker for the early detection and implementation of therapeutic strategies in order to reverse and prevent the DPN.
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Int. J. Clin. Pract. · Aug 2021
Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is Influenced by the Type of Transport Medium: Implications for Diagnosis and Monitoring.
It is unclear if the use of a molecular transport medium (MTM) containing guanidine isothiocyanate (GITC) would be advantageous over the CDC recommended, commonly used viral transport medium (VTM). We retested 70 SARS-CoV2 cases by RT-PCR in varying stages of follow-up using MTM and VTM in parallel and found discrepant results of RNase P, E and N genes. Majority (81%) patients tested positive with MTM as compared with VTM (27.1%). Even patients who were sampled 3 weeks after diagnosis demonstrated a significant discrepancy in the positivity rates between MTM vs VTM raising concerns about the clinical utility of VTM.
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Int. J. Clin. Pract. · Aug 2021
Can Serum Matrix Metalloproteinase-9 and SMAD-2 Levels Predict Lamina Propria Invasion in Bladder Urothelial Carcinoma?
Matrix metalloproteinase-9 (MMP-9) has a role in the destruction of lamina propria (LP) of the bladder wall and SMAD-2 promotes cell-to-cell adhesion. This study aimed to investigate the association between LP invasion and serum protein and mRNA expression levels of MMP-9 and SMAD-2 in bladder cancer (BC) patients. ⋯ The protein levels of MMP-9 and SMAD-2 were increased in BC patients while mRNA expressions were not different. Furthermore, the increased protein level of MMP-9 in T1 patients was more pronounced which may be related to LP invasion of the tumor.
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Int. J. Clin. Pract. · Aug 2021
Health-related quality of life and lifestyle changes in patients with chronic kidney disease and hyperkalemia: Real-world data from the US, five European countries and China.
Chronic kidney disease patients have impaired health-related quality of life and an increased risk of hyperkalaemia. ⋯ Hyperkalaemia is associated with an incremental impairment of the health-related quality of life in chronic kidney disease patients. A better understanding of the impact of hyperkalaemia in these patients could improve patient outcomes.