Critical care : the official journal of the Critical Care Forum
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Gastrointestinal feeding intolerance and critical illness-associated gastric motility dysfunction are common. Although recent guidelines recommend not interrupting gastric feeding when gastric residual volume (GRV) is lower than 500 mL or to completely abandon measurement of GRV, it may seem that the relevance of prokinetics is reduced. ⋯ Metoclopramide and erythromycin are commonly used promotility agents, although with relevant side effects. Potential targets for new agents and early study results are addressed.