Neuromodulation : journal of the International Neuromodulation Society
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Objectives. This study was designed to assess vagus nerve stimulation effects on the food intake pattern in swine and determine the electrical stimulus direction. Material and Methods. Fifteen Large White pigs were randomly divided into three groups, groups A-C. All animals underwent implantation of a vagus nerve stimulator at the gastro-esophogeal junction. ⋯ Results. With respect to food intake, there was no difference between groups A and B; however, body weight did register a continuous increase. During stimulation, in group C arterial pressures decreased significantly, whereas the heart rate and bispectral index increased. Conclusion. The stimulation protocol applied in this study was insufficient to cause changes in the feeding behavior of swine; however, it did increase central nervous system activity.