Bulletin of experimental biology and medicine
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Bull. Exp. Biol. Med. · May 2001
Effect of enterosorbent noolith on behavior and serotonin (1A) receptors in mouse brain.
Protective properties of a new enterosorbent noolith (lithium ions immobilized on mineral matrix) were studied in C57Bl/6J mice predisposed to depression caused by intermale confrontations. The drug was administered daily for 15 days after the 5th confrontation and then the animals were tested in the forced swimming test. ⋯ Moreover, noolith reduced the number of 1A-serotonin receptors in the frontal cortex and hypothalamus. It is concluded that noolith possesses protective properties.