Bulletin of experimental biology and medicine
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Bull. Exp. Biol. Med. · Dec 2008
Hypothesis on reciprocal interactions between the central and peripheral components of the endogenous opioid system.
A hypothesis on reciprocal interactions between the central and peripheral components of the endogenous opioid system was formulated on the basis of results of our experimental studies and published data. In order to verify this hypothesis, we studied the effects of peripheral administration of loperamide (mu-opioid receptor agonist) and methylnaloxone (opioid receptor antagonist) not penetrating through the blood-brain barrier on the pain sensitivity of rats, morphine-induced analgesia, and formation of morphine analgesia tolerance. Peripheral loperamide and methylnaloxone modulated the central mechanisms of perception of painful stimuli. ⋯ Methylnaloxone and loperamide partially prevented the development of morphine analgesia tolerance. Hence, the results confirm the hypothesis about the reciprocal interactions between the central and peripheral compartments of the endogenous opioid system. The relationships between the central and peripheral compartments of the opioid system can be more intricate when its function is modulated.