Bulletin of experimental biology and medicine
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Bull. Exp. Biol. Med. · Oct 2010
Short highly intense exercise causes changes in salivary concentrations of hydrocortisone and secretory IgA.
The dynamics of salivary hydrocortisone during exercise depends on the professional status of the athlete. Hydrocortisone concentrations increase and those of secretory IgA decrease significantly during short-term highly intense exercise. Presumably, basal serum hydrocortisone level is the key factor in restoration of the secretory IgA concentration after exercise by inhibition of lymphocyte, macrophage, and monocyte functions through an increase in glucocorticoid level under the effect of physiological stressors.
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Bull. Exp. Biol. Med. · Oct 2010
Matrix metalloproteinases 2, 7, and 9 and tissue inhibitor of metalloproteinases-1 in tumors and serum of patients with ovarian neoplasms.
The content of matrix metalloproteinases 7 and 9 was significantly increased, while the content of metalloproteinase 2 was reduced in ovarian cancer tissue compared to benign tumors. In blood serum from patients with ovarian cancer, the concentrations of matrix metalloproteinases 7 and 9 and their type 1 tissue inhibitor were significantly elevated, while the concentration of matrix metalloproteinase 2 was reduced compared to the corresponding parameters in healthy women. After chemotherapy, tissue and serum concentrations of metalloproteinases and their inhibitor in patients practically returned to normal. A significant positive correlation between serum levels of matrix metalloproteinases 7 and 9 and tissue inhibitor of metalloproteinases-1 in patients with ovarian cancer and the size of primary tumor (ultrasound examination) and a positive correlation between these parameters and the concentration of classical ovarian cancer marker CA-125 were demonstrated.