Journal of oral science
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Journal of oral science · Mar 2014
Effect of basic fibroblast growth factor on angiogenesis and bone regeneration in non-critical-size bone defects in rat calvaria.
We used microcomputed tomography (micro-CT) to evaluate the effects of basic fibroblast growth factor (FGF-2) contained in absorbable collagen sponges on angiogenesis and bone regeneration in rat calvarial non-critical-size bone defects. Two symmetrical non-critical-size calvarial bone defects (diameter, 2.7 mm) were created in male Fisher rats. ⋯ On day 28, blood vessel volume and bone volume were significantly greater in the 0.3% and 0.1% FGF-2 groups than in the control group. FGF-2 concentration-dependently increased blood vessels and bone formation in non-critical-size bone defects in rat calvaria.
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Journal of oral science · Mar 2014
Isoproterenol facilitates GABAergic autapses in fast-spiking cells of rat insular cortex.
In the cerebral cortex, fast-spiking (FS) cells are the principal GABAergic interneurons and potently suppress neural activity in targeting neurons. Some FS neurons make synaptic contacts with themselves. Such synapses are called autapses and contribute to self-inhibition of FS neural activity. β-Adrenoceptors have a crucial role in regulating GABAergic synaptic inputs from FS cells to pyramidal (Pyr) cells; however, the β-adrenergic functions on FS autapses are unknown. ⋯ Previous studies found that isoproterenol (100 μM) had pleiotropic effects on unitary inhibitory postsynaptic currents (uIPSCs) in FS→Pyr connections, whereas autapses in FS cells were always facilitated by isoproterenol. Facilitation of autapses by isoproterenol was accompanied by decreases in the paired-pulse ratio of second to first uIPSC amplitudes and the coefficient of variation of the uIPSC amplitude, which suggests that β-adrenergic facilitation is likely mediated by presynaptic mechanisms. The discrepancy between isoproterenol-induced modulation of uIPSCs in FS autapses and in FS→Pyr connections may reflect the presence of different presynaptic mechanisms of GABA release in each synapse.
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Journal of oral science · Sep 2013
Case ReportsPemphigus, discoid lupus erythematosus, and dermatomyositis during an 8-year follow-up period: a case report.
A 36-year-old Thai woman presented with a painful, burning sensation in the gingiva and desquamative gingivitis. Findings from histopathologic and direct immunofluorescence examination of the maxillary gingiva confirmed a diagnosis of pemphigus. Two months later, she developed a round erythematous lesion on her face, and findings from a skin biopsy were consistent with lupus erythematosus. ⋯ There are no previous reports of pemphigus, discoid lupus erythematosus, and dermatomyositis in a Thai patient. Fluocinolone acetonide 0.1% in Orabase and systemic steroid were effective in treating oral PV in this patient. The gingiva showed complete remission after 10 months of treatment and remission with recession at 8.5 years of follow-up.
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Journal of oral science · Mar 2013
Case ReportsOral soft-tissue angiolipoma: report of two cases of rare oral lipomatous lesion with emphasis on morphological and immunohistochemical features.
Oral angiolipomas are exceedingly rare and little is known about their morphological and etiological features. Here, we report two cases of oral angiolipoma and discuss their clinicopathological and immunohistochemical features, focusing on endothelial markers. ⋯ Immunohistochemical analysis showed numerous mast cells and expression of CD34, vascular endothelial growth factor, intercellular adhesion molecule-1, interferon-γ and interleukin 6 in most endothelial and stromal cells. Mast cell-endothelial cell interaction may be responsible for the reactive or neoplastic origin of the vascular proliferation of these entities.
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Journal of oral science · Mar 2012
Use of the Arabic version of Oral Health Impact Profile-14 to evaluate the impact of periodontal disease on oral health-related quality of life among Jordanian adults.
We used the short-form of the Oral Health Impact Profile (OHIP-14) to assess the impact of periodontal diseases on the quality of life of Jordanian adults. A systematic random sample of 400 individuals was selected from patients referred to the periodontics clinic at the Dental Teaching Center in Irbid, Jordan. Those willing to participate were examined by specifically trained dentists and requested to complete the Arabic short-form version of the OHIP-14 questionnaire. ⋯ There was a statistically significant association between the severity of periodontal disease and OHIP-14 scores (P < 0.05). Severe chronic periodontitis had a significantly greater impact on quality of life, specifically with regard to physical pain and physical disability (P < 0.05). Physical pain and physical disability were the dimensions most affected, and all OHIP-14 scores were significantly associated with severity of periodontal disease after adjusting for common confounders.