Canadian journal of surgery. Journal canadien de chirurgie
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The conventional treatment of peptic ulcer disease with special dietary regimens, antacids or anticholinergics has been found wanting. Recently introduced agents show considerable promise in the benefit they can render. ⋯ Cimetidine, a histamine HI-receptor antagonist, is an effective suppressant of acid secretion and therefore promotes healing of duodenal ulcers. Metoclopramide hastens gastric emptying and increases the tone of the gastroesophageal sphincter, and is valuable in cases of reflux esophagitis and gastric ulcer.