Med Phys
-
In image-guided laparoscopy, optical tracking is commonly employed, but electromagnetic (EM) systems have been proposed in the literature. In this paper, we provide a thorough comparison of EM and optical tracking systems for use in image-guided laparoscopic surgery and a feasibility study of a combined, EM-tracked laparoscope and laparoscopic ultrasound (LUS) image guidance system. ⋯ The errors incurred by optical trackers, due to the lever-arm effect and variation in tracking accuracy in the depth direction, would make EM-tracked solutions preferable if the EM sensor is placed at the proximal end of the laparoscope.
-
Comparative Study
Comparative study of algorithms for synthetic CT generation from MRI: Consequences for MRI-guided radiation planning in the pelvic region.
Magnetic resonance imaging (MRI)-guided radiation therapy (RT) treatment planning is limited by the fact that the electron density distribution required for dose calculation is not readily provided by MR imaging. We compare a selection of novel synthetic CT generation algorithms recently reported in the literature, including segmentation-based, atlas-based and machine learning techniques, using the same cohort of patients and quantitative evaluation metrics. ⋯ Overall, machine learning and advanced atlas-based methods exhibited promising performance by achieving reliable organ segmentation and synthetic CT generation. DCNN appears to have slightly better performance by achieving accurate automated organ segmentation and relatively small dosimetric errors (followed closely by advanced atlas-based methods, which in some cases achieved similar performance). However, the DCNN approach showed higher vulnerability to anatomical variation, where a greater number of outliers was observed with this method. Considering the dosimetric results obtained from the evaluated methods, the challenge of electron density estimation from MR images can be resolved with a clinically tolerable error.
-
Intraductal papillary mucinous neoplasms (IPMNs) are radiographically visible precursor lesions of pancreatic cancer. Despite standard criteria for assessing risk, only 18% of cysts are malignant at resection. Thus, a large number of patients undergo unnecessary invasive surgery for benign disease. The ability to identify IPMNs with low or high risk of transforming into invasive cancer would optimize patient selection and improve surgical decision-making. The purpose of this study was to investigate quantitative CT imaging features as markers for objective assessment of IPMN risk. ⋯ The present study demonstrates that features extracted from pretreatment CT images can predict the risk of IPMN. Development of a preoperative model to discriminate between low-risk and high-risk IPMN will improve surgical decision-making.