Kaohsiung J Med Sci
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Kaohsiung J Med Sci · Sep 2008
Accumulation of Tc-99m HL91 in tumor hypoxia: in vitro cell culture and in vivo tumor model.
Hypoxic cells within a tumor can account, in part, for resistance to radiotherapy and chemotherapy. Indeed, the oxygenation status has been shown to be a prognostic marker for the outcome of therapy. The purpose of this study was to determine whether Tc-99m HL91 (HL91), a noninvasive imaging tracer, detects tumor hypoxia in vitro in cell culture and in vivo in a tumor model. ⋯ HL91 accumulation in tumor hypoxia was markedly increased in mice treated with hydralazine compared with those treated with PBS. Autoradiography revealed high HL91 uptake in the peripheral areas around the necrotic regions of the tumor, which were identified by histologic examination. HL91 exhibits selectivity for tumor hypoxia both in vitro and in vivo and provides a successful imaging modality for the detection of tumor hypoxia in vivo.
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Kaohsiung J Med Sci · Sep 2008
Case ReportsCatheter migration after implantation of an intrathecal baclofen infusion pump for severe spasticity: a case report.
We report a case of intrathecal baclofen infusion pump implantation complicated by migration of the catheter tip. A 55-year-old man required an intrathecal baclofen infusion for severe spasticity 4 years after a cervical spinal cord injury with incomplete tetraparesis. Twelve months after initial implantation of the device, the patient began to experience a recurrence of trunk tightness and spasticity. ⋯ After surgery, the patients spasticity improved and, 1 year later, he has experienced no further complications during follow-up, requiring an average baclofen dose of 150 microg/day. Here, we describe several surgical methods intended to secure the intrathecal catheter and prevent catheter migration. Other complications related to catheter failure are also highlighted.