J Buon
-
Clinical Trial
Concomitant administration of uracil-tegafur and leucovorin during adjuvant radiotherapy for locally advanced rectal cancer.
We report the feasibility and toxicity profile, and the impact on local control, disease-free survival and overall survival rates of our study which consisted of postoperative concurrent chemoradiotherapy, followed by adjuvant chemotherapy using uracil-tegafur (UFT)/leukovorin (LV) in locally advanced rectal cancer patients. ⋯ The acute toxicity profile of UFT/LV, local control, disease-free survival and overall survival in the concurrent chemoradiotherapy setting for operated, locally advanced rectal cancer seem comparable with the standard 5-fluorouracil (5-FU)-based therapies.
-
Preoperative radiotherapy (RT) at high-dose short-course or at conventional fractions for rectal cancer has proven effect in increasing the tumor control. The aim of this study was to test the impact of 2 different preoperative RT schemes on local recurrence, distant metastasis and survival rates and to defi ne the indications for each of them. ⋯ The conventional preoperative RT with 50 Gy proved more effective for advanced rectal cancer (T4 or N2) and for sphincter-saving resections for lower-lying tumors. The short scheme 5 x 5 Gy is appropriate for less advanced tumors (T2-3, N0-1), therefore requiring accurate clinical staging.
-
To determine the efficacy, toxicity and survival of concurrent therapy with vinorelbine and a platinum compound with radiotherapy (RT), followed by consolidation chemotherapy with the same drugs, for locally advanced non small cell lung cancer (NSCLC). ⋯ Preliminary analysis indicates that concurrent vinorelbine and a platinum compound with RT followed by consolidation chemotherapy with the same drugs for advanced stage III NSCLC is well tolerated, has considerable activity and positive impact on survival.
-
To evaluate the role of some nuclear medicine approaches such as (99m)Tc-MIBI scan and (131)I whole-body scintigraphy (WBS) in the monitoring of patients with differentiated thyroid cancer (DTC). ⋯ (99m)Tc-MIBI scan has been reported to be a highly sensitive technique for the detection of DTC metastases that have lost the capability to uptake (131)I; the combined (99m)Tc-MIBI scintigraphy and serum Tg estimation appear to be an alternative method of radioiodine imaging in cases with DTC and elevated Tg.