American journal of veterinary research
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To evaluate the oncotic, hemodilutional, and hemostatic effects of IV infusions of a large volume of isotonic saline solution and 2 doses of 6% hydroxyethyl starch (HES) in clinically normal ponies. ⋯ Infusion of HES in clinically normal ponies increases COP, and exerts dose-dependent hemodilutional effects and dose-dependent effects on specific hemostatic variables. Thus, HES may be useful for resuscitative fluid treatment of horses.
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Comparative Study
Effects of sample handling on total carbon dioxide concentrations in canine and feline serum and blood.
To determine whether underfilling blood collection tubes leads to in vitro reduction in serum measured total CO2 concentration ([TCO2]m) in canine and feline blood samples sufficient to create the impression of metabolic acidosis (pseudometabolic acidosis) or high anion gap. ⋯ Underfilling blood collection tubes results in a false decrease in serum [TCO2], which can contribute in part to descrepancies between blood gas and chemical analyses as estimates of plasma bicarbonate concentration. This, and other in vitro effects of sample handling and collection, may result in a false assessment of metabolic acidosis in dogs and cats.
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To determine whether continuous venovenous hemofiltration, proposed to remove inflammatory mediators from circulation, would resolve cardiopulmonary derangements in a model of established endotoxic shock. ⋯ Continuous venovenous hemofiltration needs further investigation before it can be recommended as a clinically effective treatment.
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To evaluate selected cardiopulmonary responses to propofol 2 infusion rates in nonpretreated llamas breathing room air. ⋯ Propofol infusion rate of 0.2 mg/kg/min was considered too low to maintain a suitable depth of anesthesia, but 0.4 mg/kg/min was considered sufficient for noninvasive procedures with minimal cardiopulmonary depression.
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Comparative Study
Pharmacokinetics of flunixin meglumine in healthy foals less than twenty-four hours old.
To determine pharmacokinetic variables that describe the disposition of flunixin after i.v. administration of flunixin meglumine to foals < 24 hours old. ⋯ Although additional factors (eg, dehydration or sepsis) must be considered on a case-by-case basis, flunixin meglumine should be administered differently to foals < 24 hours old, compared with adults. Under similar clinical circumstances, doses in foals should be increased by as much as 1.5 times to induce comparable therapeutic concentrations; longer dose intervals, on the basis of clinical response, would be necessary to avoid drug toxicity.