Minerva anestesiologica
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Minerva anestesiologica · Oct 2011
WITHDRAWN The analgesic effect of paracetamol when added to lidocaine for intravenous regional anesthesia.
Ninety patients undergoing elective hand surgery with IVRA were randomly assigned to three groups to receive either IV saline and C-IVRA with 0.5% lidocaine 3 mg/kg (control group, N=30), IV saline and IVRA with 0.5% lidocaine and 20 mL paracetamol (10 mg/cc) (P-IVRA group, N=30) or IV paracetamol and IVRA with 0.5% lidocaine (L-IV group, N=30). The following were measured: 1) sensory and motor block onset and recovery time, 2) tourniquet pain after tourniquet application and at 10, 20 and 30 min after tourniquet deflation, 3) the visual analog scale (VAS) scores of tourniquet pain at 30 min and 1, 2, 4, 6 and 24 h postoperatively, 4) the time to first analgesic requirement, 5) total analgesic consumption in 24 h and 6) side effects. ⋯ Perfalgan as an adjunct to lidocaine improves postoperative analgesia in IVRA without adverse effects.
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Ahead of Print article withdrawn by publisher Although anesthesia has become increasingly safe, there remain significant differences among countries in terms of training standards and practice regulations. There is evidence and widespread consensus that the occasional practice of pediatric anesthesia should be avoided, and there is a trend towards the centralization of pediatric surgical activity. ⋯ In recent years, focus has been directed at validating the efficacy of simulation training and at its cost-effectiveness for improving learning and patient outcomes. Future challenges will include the best way to integrate simulation into the existing pediatric anesthesia training curricula, the determination of better evidence of its impact on clinical performance and the design and validation of assessment tools for technical and non-technical skills.
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Minerva anestesiologica · Oct 2011
WITHDRAWN Coronary artery spasm associated with blood brain barrier disruption induced by carotid sinus stimulation.
Ahead of Print article withdrawn by publisher Blood brain barrier disruption (BBBD) is a novel technique for treating central nervous system lymphoma. This technique depends on the disruption of the tight junctions between endothelial cells (which represent the blood brain barrier) by intra-arterial injection of mannitol. ⋯ Here, the authors present a rare complication of coronary artery spasm manifested by elevation of the ST segment and bradycardia due to carotid sinus stimulation in a 33 year-old-male during blood brain barrier disruption. To the authors' knowledge, this is the first report of a coronary artery spasm complicating blood brain barrier disruption.
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Sepsis is a significant public health problem that affects children and adults alike. Despite some similarities in the approach to pediatric and adult septic shock, there are key differences as it relates to pathophysiology, clinical presentation, and therapeutic approaches. In this review article, we discuss these differences under 4 headings: a) Developmental differences in the hemodynamic response, b) Activated Protein C, c) Thrombocytopenia associated multiple organ failure and d) Hemophagocytic Lymphohistiocytosis (HLH).