World Neurosurg
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Review
Craniosynostosis in Africa: Insights from Eight Countries-A Systematic Review and Meta-Analysis.
Craniosynostosis is a congenital skull deformity that impacts development and quality of life of children if left untreated. This study aimed to evaluate literature regarding presentation, treatment and outcomes of craniosynostosis in Africa. ⋯ Few studies on craniosynostosis in Africa highlight the need for more research. Treatment with open techniques yields few complications and a low mortality rate. Early diagnosis and collaborative data reporting will enhance understanding of its burden and variations across Africa.
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This study examines patients with metastatic spinal disease undergoing non-total en bloc spondylectomy, focusing on revision surgery reasons and its effectiveness in treating spinal instability, neurological issues, and pain. ⋯ Long-segment fixation with radiotherapy may reduce revision surgery need and extend the time between surgeries. Hybrid or separation surgeries lower the likelihood of revision. Revision surgery can relieve pain and improve neurological function. Patients in the revision group have longer survival times.
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Patients with residual adolescent idiopathic scoliosis (AIS) and thoracolumbar/lumbar curves may present with progression after cessation of growth, with lateral translation as a major risk factor. Nonetheless, radiographic predictors and underlying mechanisms remain indefinite. This study aimed to determine these radiographic predictors and structural mechanisms in patients with residual AIS. ⋯ Facet joint instability, L4 tilt ≥20.5°, and L3 cranial vertebral bridging are predictive radiographic factors for L3 lateral translation in patients with residual AIS. Thus, patients exhibiting these characteristics require consistent follow-up or early surgical intervention before lateral translation occurs.
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Acute traumatic spinal cord injury (SCI) results in a lifelong condition without any standardized biomarker or corresponding interventions. The objective of this study was to correlate changes in fluid biomarkers with the severity of SCI. ⋯ A negative correlation was observed between biomarkers and functional outcome scores with statistical significance for the 100 kdyn injury. As such, this study demonstrates the potential usefulness of these biomarkers in SCI, especially with regards to impact severity. Futures studies may be conducted at various impact forces to establish a biomarker gradient based on severity of injury.