Ann Pathol
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Case Reports
[Disseminated histoplasmosis caused by Histoplasma capsulatum and sarcoidosis. Apropos of a case].
Histoplasma capsulatum can, sometimes, simulate sarcoidosis, clinically and pathologically. A case is reported in which disseminated histoplasmosis is proved only by fungus granulomatous tissue. ⋯ Lesions pathogeny was discussed. In our case it's not possible to eliminate the role of primary sarcoidosis in disseminated histoplasmosis.
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Comparative Study
[Lymphomatoid granulomatosis, polymorphic reticulosis and angioimmunoblastic lymphadenopathy with pulmonary involvement. Similar or different entities?].
This study attempts to demonstrate that typical lymphomatoid granulomatosis, polymorphic reticulosis and angioimmunoblastic lymphadenopathy with pulmonary involvement, are three related anatomo-clinical conditions. Three groups of patients with clinical and pathological signs corresponding to each of these three conditions are studied. In group A, the clinical, radiographic and histologic data for 11 patients presenting "classical lymphomatoid granulomatosis" are reported. ⋯ Lymph node lesions were typical for AIL: destruction of follicular structure, vascular proliferation and numerous immunoblasts. Lesions in other organs (mainly lung, dermal and ENM lesions) were characterized by angiocentric granulomas containing numerous blast cells. The biological behavior with eventual development of a monoclonal gammopathy, associated or not with a malignant immunoblastic lymphoma, as well as resemblance of clinical and histological manifestations during the course of the disease, suggest that these three conditions represent variants of a basically identical entity.
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Comparative Study
[Visceral histologic lesions of lethal acute colchicine poisoning. Apropos of 12 cases].
The authors reported histological characteristics (on post-mortem examination) of 12 cases of lethal acute colchicine intoxication and compare these results with the 5 previous anatomical studies of such cases in the literature. Abnormal mitosis (stathmocinesis, "caryomerie", caryorrhexis and mitonecrosis) are constant and essentially seen in the bone marrow and digestive mucosae, especially in oesophagus which squamous epithelium is more resistant to autolysis than others digestive mucosae. Biological or histological symptoms or lesions of intravascular diffuse coagulation are present 7 cases but both biological and histological manifestations in only one case. ⋯ A microvacuolar non systematized and diffuse liver fatty change is found in 10 cases, probably related to alteration of lipoproteins synthesis and secretion by hepatocytes. Interstitial myocardial oedema is a constant feature; in addition true interstitial myocarditis (with infiltration by polymorphs) is seen in two cases. These cardiac lesions may be related to the cardiogenic shock which is often observed in these patients.
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The WHO Histological Classification of Lung Tumours, published in 1967, has been revised. The main features are as follows: Squamous cell carcinoma (epidermoid carcinoma) has the same definition as in the original version, i.e., the identification of keratin and/or intercellular bridges by light microscopy. Three degrees of histological differentiation are described. ⋯ Adenocarcinoma includes the acinar, papillary and bronchiolo-alveolar forms and the solid carcinomas with mucus formation (previously part of the large cell carcinoma group). Mesothelial tumours are divided into fibrous, epithelial and biphasic subtypes. A number of less common tumours and tumour-like lesions are defined.