The Journal of clinical endocrinology and metabolism
-
J. Clin. Endocrinol. Metab. · Sep 2007
Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population.
Both circulating levels and genetic variation of IGFs have been associated with cancer risk, yet the relationship between the two is not well understood. ⋯ In summary, our study suggests that common genetic variation in IGFBP3 influences circulating levels of IGFBP-3 among African-Americans, Native Hawaiians, Japanese-Americans, Latinos, and whites.
-
J. Clin. Endocrinol. Metab. · Sep 2007
Maternal vitamin D deficiency increases the risk of preeclampsia.
Vitamin D has direct influence on molecular pathways proposed to be important in the pathogenesis of preeclampsia, yet the vitamin D-preeclampsia relation has not been studied. ⋯ Maternal vitamin D deficiency may be an independent risk factor for preeclampsia. Vitamin D supplementation in early pregnancy should be explored for preventing preeclampsia and promoting neonatal well-being.
-
J. Clin. Endocrinol. Metab. · Sep 2007
Hypothalamic-pituitary-adrenal axis function and the cellular immune response in former preterm children.
Animal data suggest that adverse early experiences may affect endocrine and immune functioning in later life. ⋯ The data suggest that preterm delivery may be associated with altered endocrine and immune functions well into late childhood.