The Journal of clinical endocrinology and metabolism
-
J. Clin. Endocrinol. Metab. · Jul 2008
Randomized Controlled Trial Comparative StudyComparison of single and combined treatment with exenatide and metformin on menstrual cyclicity in overweight women with polycystic ovary syndrome.
Insulin resistance and obesity are common features of the polycystic ovary syndrome (PCOS). Weight loss and use of insulin-lowering drugs have been shown to improve both reproductive and metabolic aspects of PCOS. ⋯ COM appears better than either EX or MET alone on menstrual cycle frequency and hormonal and metabolic derangements. A marked decrease in central adiposity could partly explain the improvements in reproductive function, insulin-glucose parameters, and adiponectin observed in these overweight women with PCOS treated with COM therapy. Larger trials of longer duration are warranted to assess the long-term efficacy and safety of combined EX-MET therapy in overweight women with PCOS.
-
J. Clin. Endocrinol. Metab. · Jul 2008
Aerobic capacity and growth hormone deficiency after traumatic brain injury.
GH deficiency occurs in approximately 20% of all individuals who suffer from a moderate to severe traumatic brain injury. ⋯ This study shows that individuals with traumatic brain injury with normal GH secretion have below normal aerobic capacity and those patients who have GH insufficiency/deficiency are further deconditioned. Studies of GH replacement in these subjects should be conducted to assess whether GH therapy can improve cardiorespiratory fitness and prevent secondary disability.
-
J. Clin. Endocrinol. Metab. · Jul 2008
Editorial CommentIodine in pregnancy: is salt iodization enough?