The Journal of clinical endocrinology and metabolism
The most recent articles from:
July 2009
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J. Clin. Endocrinol. Metab. · Jul 2009
Randomized Controlled TrialThe effect of strict blood glucose control on biliary sludge and cholestasis in critically ill patients.
Cholestatic liver dysfunction and biliary sludge are common problems in critically ill patients. No specific strategies have been described to prevent cholestasis and biliary sludge in the intensive care unit (ICU). We examined liver dysfunction and biliary sludge prospectively in a large medical long-stay ICU population and hypothesized that tight glycemic control with intensive insulin therapy (IIT) reduces cholestasis and biliary sludge. ⋯ Cholestatic liver dysfunction and biliary sludge are very common during prolonged critical illness but are significantly reduced by IIT.