The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · Oct 2010
Randomized Controlled TrialGlucose dysregulation and neurological injury biomarkers in critically ill children.
Targeting normoglycemia with intensive insulin therapy (IIT) improved short-term outcome of pediatric intensive care unit (PICU) patients but increased the incidence of hypoglycemia. Both hyperglycemia and hypoglycemia may adversely affect the developing brain. ⋯ IIT in PICU did not evoke neurological damage detectable by circulating S100B and NSE, despite increased incidence of hypoglycemia. Elevated markers in patients with hypoglycemia were not caused by hypoglycemia itself but rather reflect an increased incidence of hypoglycemia in the most severely ill. This hypoglycemia risk appears difficult to capture by classical illness severity scores.
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J. Clin. Endocrinol. Metab. · Oct 2010
Clinical TrialEffect of a single oral dose of 600,000 IU of cholecalciferol on serum calciotropic hormones in young subjects with vitamin D deficiency: a prospective intervention study.
Effects of vitamin D repletion in young people with low vitamin D status have not been investigated so far. ⋯ A single oral dose of 600,000 IU of cholecalciferol rapidly enhances 25(OH)D and reduces PTH in young people with vitamin D deficiency.