The Journal of clinical endocrinology and metabolism
-
J. Clin. Endocrinol. Metab. · Sep 2010
Meta AnalysisEffects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data.
HIV patients treated with antiretroviral therapy (ART) often develop increased visceral adipose tissue (VAT). ⋯ Treatment with tesamorelin reduces VAT and maintains the reduction for up to 52 wk, preserves abdominal sc adipose tissue, improves body image and lipids, and is overall well tolerated without clinically meaningful changes in glucose parameters.
-
J. Clin. Endocrinol. Metab. · Sep 2010
Controlled Clinical TrialThe association of preoperative glycemic control, intraoperative insulin sensitivity, and outcomes after cardiac surgery.
The impairment of insulin sensitivity, a marker of surgical stress, is important for outcomes. ⋯ In diabetic patients, HbA(1c) levels predict insulin sensitivity during surgery and possibly outcome. Intraoperative insulin resistance is associated with an increased risk of complications, independent of the patient's diabetic state.