The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · Oct 2011
Randomized Controlled TrialA one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial.
Lorcaserin is a novel selective agonist of the serotonin 2C receptor. ⋯ Lorcaserin administered in conjunction with a lifestyle modification program was associated with dose-dependent weight loss that was significantly greater than with placebo.
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J. Clin. Endocrinol. Metab. · Oct 2011
Randomized Controlled Trial Comparative StudySubstitution of standard soybean oil with olive oil-based lipid emulsion in parenteral nutrition: comparison of vascular, metabolic, and inflammatory effects.
Soybean oil-based lipid emulsions are the only Food and Drug Administration-approved lipid formulation for clinical use in parenteral nutrition (PN). Recently concerns with its use have been raised due to the proinflammatory effects that may lead to increased complications because they are rich in ω-6 polyunsaturated fatty acids. ⋯ The 24-h infusion of PN containing soybean oil-based lipid emulsion increased blood pressure and impaired endothelial function compared with PN containing olive oil-based lipid emulsion and lipid-free PN in healthy subjects. These vascular changes may have significant implications in worsening outcome in subjects receiving nutrition support. Randomized controlled trials with relevant clinical outcome measures are needed in patients receiving PN with olive oil-based and soybean oil-based lipid emulsions.
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J. Clin. Endocrinol. Metab. · Oct 2011
Review Meta AnalysisClinical review: The effect of vitamin D on falls: a systematic review and meta-analysis.
Vitamin D affects bone and muscle health and likely reduces the risk of falls in the elderly. ⋯ Vitamin D combined with calcium reduces the risk of falls. The reduction in studies without calcium coadministration did not reach statistical significance. The majority of the evidence is derived from trials enrolling elderly women.
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J. Clin. Endocrinol. Metab. · Oct 2011
Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women.
The American Heart Association Nutrition Committee recommends women and men consume no more than 100 and 150 kcal of added sugar per day, respectively, whereas the Dietary Guidelines for Americans, 2010, suggests a maximal added sugar intake of 25% or less of total energy. ⋯ Consumption of HFCS-sweetened beverages for 2 wk at 25% E increased risk factors for cardiovascular disease comparably with fructose and more than glucose in young adults.
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J. Clin. Endocrinol. Metab. · Oct 2011
Sunitinib-induced hypothyroidism is due to induction of type 3 deiodinase activity and thyroidal capillary regression.
Anticancer treatment with the tyrosine kinase inhibitor sunitinib causes thyroid dysfunction. ⋯ Sunitinib induces hypothyroidism due to alterations in T(4)/T(3) metabolism as well as thyroid capillary regression.