The Journal of clinical endocrinology and metabolism
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J. Clin. Endocrinol. Metab. · Dec 2013
Randomized Controlled Trial Multicenter Study Comparative StudyA randomized trial of vitamin D₃ supplementation in children: dose-response effects on vitamin D metabolites and calcium absorption.
Changes in serum vitamin D metabolites and calcium absorption with varying doses of oral vitamin D₃ in healthy children are unknown. ⋯ Large increases in serum 25(OH)D with vitamin D₃ supplementation did not increase calcium absorption in healthy children living at 2 different latitudes. Supplementation with 400 IU/d was sufficient to maintain wintertime 25(OH)D concentrations in healthy black, but not white, children.
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J. Clin. Endocrinol. Metab. · Dec 2013
Randomized Controlled Trial25-Hydroxyvitamin D response to graded vitamin D₃ supplementation among obese adults.
Guidelines have suggested that obese adults need 2 to 3 times more vitamin D than lean adults to treat vitamin D deficiency, but few studies have evaluated the vitamin D dose response in obese subjects. ⋯ Our data show that in obese people, the 25(OH)D response to vitamin D₃ is directly related to dose and body size with ∼2.5 IU/kg required for every unit increment in 25(OH)D (nanograms per milliliter).
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J. Clin. Endocrinol. Metab. · Dec 2013
Multicenter StudyObservational study of natural history of small sporadic nonfunctioning pancreatic neuroendocrine tumors.
Asymptomatic sporadic nonfunctioning, well-differentiated pancreatic neuroendocrine tumors (NF-PNETs) are increasingly diagnosed, and their management is controversial because of their overall good but heterogeneous prognosis. ⋯ In selected patients, nonoperative management of asymptomatic sporadic NF-PNETs smaller than 2 cm in size is safe. Larger and prospective multicentric studies with long-term follow-up are now needed to validate this wait-and-see policy.
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J. Clin. Endocrinol. Metab. · Dec 2013
Five-year follow-up for women with subclinical hypothyroidism in pregnancy.
Increasing numbers of women are being treated with l-thyroxine in pregnancy for mild thyroid dysfunction because of its association with impaired neuropsychological development in their offspring and other adverse obstetric outcomes. However, there are limited data to indicate whether treatment should be continued outside of pregnancy. ⋯ The majority of cases of subclinical hypothyroidism in pregnancy are transient, so treatment with l-thyroxine in these patients should be reviewed because it may not be warranted after pregnancy.